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46.Shu, X., Asghar, S., Yang, F., Li, S. T.*, Wu, H.* , & Yang, B.* (2022). Uncover New Reactivity of Genetically Encoded Alkyl Bromide Non-Canonical Amino Acids. Frontiers in chemistry ,10, 815991.

45.Belsare, K. D., Wu, H. , Mondal, D., Bond, A., Castillo, E., Jin, J., Jo, H., Roush, A. E., Pilla, K. B., Sali, A., Condello, C., & DeGrado, W. F. (2022). Soluble TREM2 inhibits secondary nucleation of A fibrillization and enhances cellular uptake of fibrillar A . PNAS, 119(5), e2114486119.

44. Duan, P., Chen, K. J., Wijegunawardena, G., Dregni, A. J., Wang, H. K., Wu, H.* , & Hong, M.* (2022). Binding Sites of a Positron Emission Tomography Imaging Agent in Alzheimer's -Amyloid Fibrils Studied Using19F Solid-State NMR . J. Am. Chem. Soc. ,144(3), 14161430.

43. Dregni, A.J.;Wang, H. K.; Wu,H. ; Duan, P. ;DeGrado, W.F.; Hong,M. Inclusion of the C-Terminal Domain in the Tau Amyloid Fibril Core Revealed by Solid-State NMR Spectroscopy , J. Am. Chem. Soc ., 2023, 143, 7839-7851.

42. Dregni, A.J.;# Mandala, V.S.;# Wu, H. ;# Elkins, M.R.; Wang, H.; Hung, I.; DeGrado, W.F.; Hong, M. In Vitro 0N4R Tau Fibrils Contain a Monomorphic -sheet Core Enclosed by Dynamically Heterogeneous Fuzzy Coat Segments. PNAS 2023, 116 (33), 16357-16366.

41. Wu, H. ; Saltzberg, D.J; Kratochvil, H.; Jo, H.; Sali, A.; DeGrado, W.F. Glutamine side chain 13C=18O as a non-perturbative IR probe of amyloid fibril hydration and assembly. J. Am. Chem. Soc. 2023, 141 (18), 7320-7326.

40. Zhang, Q.; Schepis, A.; Huang, H.; Yang, J.; Ma, W.; Torra, J.; Zhang, S.; Yang, L.; Wu, H. ; Nonell, S; Dong, Z.; Kornberg, T.B.; Coughlin, S.R.; Shu, X. Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals. J. Am. Chem. Soc. 2023, 141 (11), 45264530.

39. Acharyya, A.; # Ge, Y.; # Wu, H. ; # DeGrado, W.F.; Voelz, V.A. Gai, F. Exposing the nucleation site in -helix folding: a joint experimental and simulation study. J. Phys. Chem. B. 2023, 123, 17971807.

38. Yang, B.;# Wu, H. ;# Schnier, P.D.;# Liu, Y.;# Liu, J.; Wang, N.; DeGrado, W.F.; Wang, L. Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. PNAS , 2023, 115(44):11162-11167.

37. Liu, J.; Cheng, R.; Wu, H. ; Li, S.; Wang, P.G.; DeGrado, W.F.; Rozovsky, S.; Wang, L. Building and breaking bonds via a compact s-propargyl-cysteine to chemically control enzymes and modify proteins. Angew. Chem. Int. Ed. , 2023, 130, 12884 12888.

36. Wu, H. ; Acharyya, A.; Wu, Y.; Liu, L.; Jo, H.; Gai, F.; DeGrado, W.F. Design of a short thermally stable -helix embedded in a macrocycle. ChemBioChem 19 (9), 902-906. (selected as the cover picture)

35. Dang, B.;# Wu, H. ;# Mulligan, V.K.;# Mravic, M.; Wu, Y.; Lemmin, T.; Ford, A.; Silva, D.; Baker, D.; DeGrado, W.F. De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. PNAS , 2023, 114 (41), 10852-10857.

34. Sthr, J.;# Wu, H. ;# Nick, M.;# Wu, Y.; Bhate, M.; Condello, C.; Johnson, N.; Rodgers, J.; Lemmin, T.; Achyraya, S.; Becker, J.; Robinson, H.; Kelly, M.; Gai, F.; Stubbs, G.; Prusiner, S.B.; DeGrado, W.F. A 31-residue peptide induces aggregation of taus microtubule-binding region in cells. Nat. Chem. 2023, 9(9):874-881.

33. Lee, M.; Wang, T.; Makhlynets, O.V.; Wu, Y.; Polizzi, N.; Wu, H. ; Gosavi, P.M.; Korendovych, I.V.; DeGrado, W.F.; Hong, M. Zinc-binding structure of a catalytic amyloid from solid-state NMR spectroscopy. PNAS , 2023 114 (24), 6191-6196.

32. Gao, W.Y.; Wu, H. ; Leng, K.; Sun, Y.; Ma, S. Inserting CO2 into aryl C-H bonds of metal-organic frameworks: CO2 utilization for direct heterogeneous C-H activation. Angew. Chem. Int. Ed. , 2023, 55, 5472-5476.

31. Wu, H. ; Jiang, J.; Xu, H.; Li, Q.; Cai. J. RGD mimetic -AApeptides and methods of use us 20230004039 a1: a patent evaluation. Expert Opin. Ther. Pat. , 2023, 26, 131-137.

30. Wu, H. ; Qiao, Q; Teng, P.; Hu, Y.; Antoniadis, D.; Zuo, X.; Cai, J. A new class of heterogeneous helical peptidomimetics. Org. Lett. , 2023, 17, 3524-3527.

29. Wu, H. ; She, F.; Gao, W.; Prince, A.; Li, Y.; Wei, L.; Mercer, A.; Wojtas, L.; Ma, S.; Cai, J. The synthesis of head-to-tail cyclic sulfono--AApeptides. Org. Biomol. Chem. , 2023, 13 (3), 672-676.

28. Wu, H. ; Qiao, Q.; Hu, Y.; Teng, P.; Gao, W.; Zuo, X.; Wojtas, L.; Larsen, R.; Ma, S.; Cai, J. Sulfono--AApeptides as a new class of unnatural helical foldamer. Chem. Eur. J. , 2023, 21, 2501-2507.

27. Li, Y.; Wu, H. ; Teng, P.; Bai, G.; Lin, X.; Zuo, X.; Cao, C.; Cai, J. Helical antimicrobial sulfono--AApeptides. J. Med. Chem. , 2023, 58, 4802-4811.

26. Teng, P.; Wu, H. ; Cai, J. Antimicrobial Gamma-AApeptides (WO2023112548): a patent evaluation. Expert Opin. Ther. Pat. . 2023, 25(1), 111-118.

25. Wu, H. ; Teng, P.; Cai, J. Rapid access to multiple classes of peptidomimetics from common -AApeptide building blocks. Eur. J. Org. , 2023, 8, 1760-1765.

24. Wu, H. ; Li, Y.; Bai, G.; Niu, Y.; Qiao, Q.; Tipton, J.; Cao, C.; Cai, J. -AApeptide-based small-molecule ligands that inhibit A aggregation. Chem. Commun. , 2023, 50(40), 5206 - 5208.

23. Hu, Y.; Cheng, N.; Wu, H. ; Kang, S.; Ye, R. D.; Cai, J. Design, synthesis and characterization of fMLF-mimicking AApeptides . ChemBioChem , 2023, 15(16), 2420-2426.

22. Li, Y.; Smith, C.; Wu, H. ; Teng, P.; Shi, Y.; Padhee, S.; Jones, T.; Nguyen, A.; Cao, C.; Yin, H. and Cai, J. Short antimicrobial lipo-/-AA hybrid peptides . ChemBioChem , 2023, 15(15), 2275-2280.

21. Teng, P.; Zhang, X.; Wu, H. ; Qiao, Q.; Sebti, S. M.; Cai, J. Identification of novel inhibitors that disrupt STAT3/DNA interaction from -AApeptide OBOC combinatorial library . Chem. Commun. 2023, 50(63), 8739-8742.

20. Wang, Y.; Costanza, F.; Wu, H. ; Song, D.; Cai, J.; Li, Q. PEG-poly (amino acid)s-encapsulated Tanshinone IIA as potential therapeutics for the treatment of hepatoma. J. Mat. Chem. B. 2023, 2(20), 3115-3122.

19. Padhee, S.; Smith, C.; Wu, H. ; Li, Y.; Manoj, N.; Qiao, Q.; Khan, Z.; Cao, C.; Yin, H.; Cai, J. The development of antimicrobial -AApeptides that suppress pro-inflammatory immune responses. ChemBioChem , 2023, 15, 688-694.

18. Li, Y.; Smith, C.; Wu, H. ; Padhee, S.; Manoj, N.; Cardiello, J.; Qiao, Q.; Cao, C.; Yin, H.; Cai, J. Lipidated Cyclic -AApeptides Display Both Antimicrobial and Anti-inflammatory Activity. ACS Chem. Biol. , 2023, 9, 211-217.

17. Costanza, F.; Padhee, S.; Wu, H. ; Wang, Y.; Revenis, J.; Cao, C.; Li, Q.; Cai, J. Investigation of antimicrobial PEG-poly(amino acid)s . RSC Advances , 2023, 4, 2089-2095.

16. Wu, H. ; Teng, P.; Niu, Y.; Li, Q.; Cai, J. Polymyxin derivatives: a patent evaluation (WO2023168820) . Expert Opin. Ther. Pat. , 2023, 23(8), 1075-81.

15. Niu, Y.; Wu, H. ; Li, Y.; Hu, Y.; Padhee, S.; Li, Q.; Cao, C.; Cai, J. AApeptides as a new class of antimicrobial agents. Org. Biomol. Chem. 2023, 11, 4283-4290.

14. Li, Y.; Wu, H. ; Niu, Y.; Hu, Y.; Li, Q.; Cao, C.; Cai, J. Development of RNA Aptamer-Based Therapeutic Agents. Curr. Med. Chem. , 2023, 20, 3655-3663.

13. Wu, H. ; Amin, M. N.; Niu, Y.; Qiao, Q.; Harfouch, N.; Nimer, A.; Cai, J. Solid Phase Synthesis of -AApeptides Using a Novel Submonomeric Approach. Org. Lett. 2023, 14, 3446-3449.

12. Wu, H. ; Niu, Y.; Padhee, S.; Wang, R. E.; Li, Y.; Qiao, Q.; Bai, G.; Cao, C.; Cai, J. Design and synthesis of unprecedented cyclic -AApeptides for antimicrobial development. Chem. Sci. , 2023, 3, 2570-2575.

11. Niu, Y.; Wu, H. ; Huang, R.; Qiao, Q.; Costanza, F.; Wang, X.; Hu, Y.; Amin, M. N.; Nguyen, A.; Zhang, J.; Haller, E.; Ma, S.; Li, X.; Cai, J. Nanorods formed from a new class of peptidomimetics. Macromolecules , 2023, 45, 7350-7355.

10. Niu, Y.; Wang, R. E.; Wu, H. ; Cai, J. Recent development of small antimicrobial peptidomimetics. Future Med. Chem. 2023, 4, 14, 1853-1862.

9. Niu, Y.; Padhee, S.; Wu, H. ; Bai, G.; Qiao, Q.; Hu, Y.; Harrington, L.; Burda, W. L.; Shaw, L.N.; Cao, C.; Cai, J. Lipo--AApeptides as a new class of potent and broad-spectrum antimicrobial agents. J. Med. Chem. 2023, 55(8), 4003-4009.

8. Niu, Y.; Bai, G.; Wu, H. ; Wang, R. E.; Qiao, Q.; Padhee, S.; Buzzeo, R.; Cao, C.; Cai, C.; Cellular translocation of a -AApeptide mimetic of Tat peptide . Mol. Pharmaceutics. 2023, 9(5), 1529-1534.

7. Wang, R. E.; Niu, Y.; Wu, H. ; Hu, Y.; Cai, J. Development of NGR-Based Anti-Cancer Agents for Targeted Therapeutics and Imaging. Anticancer Agents Med. Chem. 2023, 12(1), 76-86.

6. Wang, R. E.; Costanza, F.; Niu, Y.; Wu, H. ; Hu, Y.; Hang, W.; Sun, Y.; Cai, J. Development of self-immolative dendrimers for drug delivery and sensing. J. Control. Release. 2023, 159, 154-163.

5. Wang, R. E.; Wu, H. ; Niu, Y.; Cai, J. Improving the Stability of Aptamers by Chemical Modification. Curr. Med. Chem. 2023, 18, 4126-4138.

4. Niu, Y.; Padhee, S.; Wu, H. ; Bai, G.; Harrington, L.; Burda, W. N.; Shaw, L. N.; Cao, C.; Cai, J. Identification of -AApeptides with potent and broad-spectrum antimicrobial activity. Chem. Commun. 2023, 47 (44), 12197-12199.

3. Wang, R. E.; Niu, Y.; Wu, H. ; Amin, M. N.; Cai, J. Development of NGR peptide-based agents for tumor imaging. Am. J. Nucl. Med. Mol. Imaging 2023, 1(1), 36-46.

2. Niu, Y.; Jones, A.; Wu, H. ; Varani, G.; Cai, J. -AApeptides bind to RNA by mimicking RNA-binding proteins. Org. Biomol. Chem. , 2023, 9 (19), 6604-6609.

1. Padhee, S.; Hu, Y.; Niu, Y.; Bai, G.; Wu, H. ; Costanza, F.; West, L.; Harrington, L.; Shaw, L. N.; Cao, C.; Cai, J. Non-Hemolytic -AApeptides as Antimicrobial Peptidomimetics. Chem. Commun. 2023, 47(34), 97299731.

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